N α-Acetylation and Proteolytic Activity of the Yeast 20 S Proteasome
نویسندگان
چکیده
منابع مشابه
S-N transfer and dual acetylation in the S-acetylation and N-acetylation of 3-phosphoglyceraldehyde dehydrogenase by substrates.
7. FUWA, K., WACKER, W. E. C., DRUYAN, R., BARTHOLOMY, A. F., AND VALLEE, B. L., Proc. Katl. Acad. Sci. U. S., 46, 1198 (1960). MAHLER, H. R., DUTTON, G., AND MEHROTRA, B. D., Biochim. et Btiphys. Acta, 68, 199 (1963). 8. 9. FRESCO, J. R., ALBERT, B. M., AND DOTY, P., Nature, 188, 98 (1960). BRUNNGRABER, E. F., Biochem. and Biophys. Research Communs., 8, 1 (1962). 10. VON EHRENSTEIN,G., AND LIP...
متن کاملN(α)-Acetylation of yeast ribosomal proteins and its effect on protein synthesis.
N(α)-Acetyltransferases (NATs) cause the N(α)-acetylation of the majority of eukaryotic proteins during their translation, although the functions of this modification have been largely unexplored. In yeast (Saccharomyces cerevisiae), four NATs have been identified: NatA, NatB, NatC, and NatD. In this study, the N(α)-acetylation status of ribosomal protein was analyzed using NAT mutants combined...
متن کاملBiochemical analysis of the 20 S proteasome of Trypanosoma brucei.
We describe here biochemical characterization of the 20 S proteasome from the parasitic protozoan Trypanosoma brucei. Similar to the mammalian proteasome, the T. brucei proteasome is made up of seven alpha- and seven beta-subunits. Of the seven beta-type subunits, five contain pro-sequences that are proteolytically removed during assembly, and three of them are predicted to be catalytic based o...
متن کاملSelective degradation of oxidized calmodulin by the 20 S proteasome.
We have investigated the mechanisms that target oxidized calmodulin for degradation by the proteasome. After methionine oxidation within calmodulin, rates of degradation by the 20 S proteasome are substantially enhanced. Mass spectrometry was used to identify the time course of the proteolytic fragments released from the proteasome. Oxidized calmodulin is initially degraded into large proteolyt...
متن کاملDNA damage-induced ubiquitylation of proteasome controls its proteolytic activity
Stability of proteins is largely controlled by post-translational covalent modifications. Among those, ubiquitylation plays a central role as it marks the proteins for proteasome-dependent degradation. Proteolytic activities of proteasomes are critical for execution of various cellular processes, including DNA damage signaling and repair. However, very little is known about the regulation of pr...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 2000
ISSN: 0021-9258
DOI: 10.1074/jbc.275.7.4635